Mannose Receptor 1 Restricts HIV Particle Release from Infected Macrophages

Mannose Receptor 1 Restricts HIV Particle Release from Infected Macrophages

Human mannose receptor 1 (hMRC1) is expressed on the surface of most tissue macrophages, dendritic cells, and select lymphatic or liver endothelial cells. HMRC1 contributes to the binding of HIV-1 to monocyte-derived macrophages (MDMs) and is involved in the endocytic uptake of HIV-1 into these cells. Here, we identify hMRC1 as an antiviral factor that inhibits virus release through a bone marr...

Mannose Receptor Promoter HIV-1 Tat Represses Transcription from the

Reduced binding and phagocytosis of Pneumocystis carinii by alveolar macrophages from persons infected with HIV-1 correlates with mannose receptor downregulation.

The macrophage mannose receptor, a pattern recognition molecule and component of innate immunity, mediates binding and phagocytosis of Pneumocystis carinii and likely represents an important clearance mechanism in the lungs of immunocompetent hosts. The purpose of this study was to examine the ability of alveolar macrophages from HIV-infected individuals to bind and phagocytose P. carinii, and ...

HIV-1-specific CTLs effectively suppress replication of HIV-1 in HIV-1-infected macrophages.

Both CD4+ T cells and macrophages are major reservoirs of HIV-1. Previous study showed that HIV-1-specific cytolytic T lymphocytes (CTLs) hardly recognize HIV-1-infected CD4+ T cells because of Nef-mediated HLA class I down-regulation, suggesting that HIV-1 escapes from HIV-1-specific CTLs and continues to replicate in HIV-1-infected donors. On the other hand, the CTL recognition of HIV-1-infec...

Autophagy restricts HIV-1 infection

Human Immunodeficiency Virus type 1 (HIV-1) is a retrovirus that targets cells from the immune system such as the CD4 T lymphocytes, the macrophages and the dendritic cells (DCs). Although these host cells possess various defense mechanisms to fight this infection, HIV-1 has evolved multiple strategies to counteract them. For the past ten years, researchers have been focused on the identificati...